Gonorrhea is the second most commonly reported notifiable disease in the United States. Since 2012, the Centers for Disease Control and Prevention (CDC) has recommended dual therapy with a single dose of 250 mg of intramuscular ceftriaxone in combination with 1 gram of oral azithromycin. However, surveillance data suggest that azithromycin resistance might be emerging. Therefore, CDC advises that clinicians should not treat gonorrhea with only azithromycin. Read the CDC clinical reminder.