The Israeli Ministry of Health is reporting an outbreak of leptospirosis in persons with exposure to natural water sources in the Golan Heights region of northern Israel after July 1, 2018. Clinicians should consider leptospirosis as a diagnosis in any patient who develops an acute febrile illness within four weeks of travel to recreational water sites in this region since July 1, 2018. If clinicians suspect leptospirosis in a patient, they should initiate treatment with antibiotics prior to receiving results of diagnostic tests, as earlier treatment is associated with a decrease in duration and severity of disease. Read the CDC health advisory.